A Cool Way to Remove Common Warts and Benign Lesions

Histofreezer® Portable Cryosurgical System FAQs

The following are frequently asked questions about the Histofreezer Portable Cryosurgical System from OraSure Technologies, Inc., a product only available to the professional market. For additional information, please contact Customer Care.

  1. How can I purchase the Histofreezer Portable Cryosurgical System?
  2. What types of lesions can I treat with the Histofreezer Portable Cryosurgical System?
  3. My practice is a business too, how do I get paid?
  4. Can non-doctors administer the procedure?
  5. Can I get additional training materials for the Histofreezer Portable Cryosurgical System?
  6. Do you have information that I can give to my patients about the procedure?
  7. What Histofreezer kit configurations are available for purchase from my supplier?
  8. How many treatments will it take to resolve a lesion?
  9. What is the shelf life of the product?
  10. Do I need to store the Histofreezer Portable Cryosurgical System kit in the freezer or refrigerator?
  11. How effective is the Histofreezer Portable Cryosurgical System product?
  12. How many applications can you perform with one saturated Histofreezer applicator?
  13. When using the Histofreezer Portable Cryosurgical System, do I need to perform a freeze-thaw-freeze procedure during a single patient visit?
  14. What is the best technique to ensure the applicator bud reaches the right temperature?
  15. How cold does the applicator get?
  16. Can I re-use the applicator buds?
  17. Can Histofreezer treat vaginal or cervical condyloma?
  18. What happens if the cryogen gas drips onto the floor or clothing?
  1. How can I purchase the Histofreezer Portable Cryosurgical System?

    The Histofreezer products are only sold through Medical/Surgical distributors. Please contact our Customer Care Department (customercare@OraSure.com) for help locating an authorized distributor in your area.

    back to top
  2. What types of lesions can I treat with the Histofreezer Portable Cryosurgical System?

      Verruca Vulgaris (common warts):

      A common wart of the skin or mucosa. The warts are round firm skin-colored papules with a hyperkeratotic (thickening) papillary surface. Sizes range between 1 to 10 mm. The hands, fingers and knees are common sites. Thrombosed capillaries which appear as black dots can be seen on the surface of some warts.

      Verruca Plantaris (plantar warts):

      Painful, unappealing benign tumors on the sole of the feet caused by the Human Papillomavirus (HPV-1) when it enters the skin through a cut or skin erosion. These warts can generally be characterized as rough, round-oval growths that can be lighter or darker than their surroundings.

      Verruca Plana:

      Also known as a "flat wart", round or oval shaped, only slightly elevated and sharply defined. They may induce however significant disturbances of pigmentation anywhere from flesh-colored in appearance to dark brown. Auto inoculation by scratching can result in linearly grouped lesions. Location of these lesions is commonly found on the forehead, cheeks, perioral (tissues around the mouth) as well as the dorsal side of hands and arms.

      Molluscum Contagiosum:

      A contagious disease of the skin caused by intranuclear proliferation of a virus of the family Poxviridae and characterized by the appearance of small, pearly, umbilicated papular epidermal growths. In adults it typically occurs on or near the genitals and is sexually transmitted.

      Acrochordon:

      Common benign skin growths (a/k/a skin tags) that occur most often after midlife. They are tiny skin protrusions, and may have a small narrow stalk connecting the skin bump to the surface of the skin. The origin is unknown however is believed to be an inherited indication.

      Actinic Keratosis:

      A premalignant warty lesion occurring on the sun-exposed skin of the face or hands in aged light-skinned persons; hyperkeratosis may form a cutaneous horn, and squamous cell carcinoma of low-grade malignancy may develop in a small proportion of untreated patients.

      Lentigo:

      A brown macule resembling a freckle except that the border is usually regular, and microscopic proliferation of rete ridges is present; scattered melanocytes are seen in the basal cell layer.

      Seborrheic Keratoses:

      Superficial, benign, verrucous, often pigmented, greasy lesions consisting of proliferating epidermal cells, resembling basal cells, enclosing horn cysts; they usually occur after the third decade.

      Condyloma Acuminata:

      A warty growth on the external genitals or at the anus, consisting of fibrous overgrowths covered by thickened epithelium showing koilocytosis, due to sexually transmitted infection with human papilloma virus; malignant change is associated with particular types of the virus.

    back to top
  3. My practice is a business too, how do I get paid?

    Cryosurgery is recognized by most insurance companies. Please see the CPT codes section of our website for reimbursement related information. Please also contact your insurance company for confirmation.

    back to top
  4. Can non-doctors administer the procedure?

    Typically yes, but check with your licensing governing body for confirmation.

    back to top
  5. Can I get additional training materials for the Histofreezer Portable Cryosurgical System?

    Yes. There is a training/procedure video, patient guide pad and in-office display available at no charge. Please contact customercare@OraSure.com for more details.

    back to top
  6. Do you have information that I can give to my patients about the procedure?

    Yes. Click here to print a patient brochure for your practice.

    back to top
  7. What Histofreezer kit configurations are available for purchase from my supplier?

    H-30 Convenience Kit Small

    H-30 Convenience Kit Small

    • Ideal for every exam room and practices treating a variety   of different lesion

    • Lower cost per treatment – No Freeze-Thaw-Freeze   Procedure

    • 80mL cryogen canister with 15 (2mm) and 15 (5mm)   applicators, detailed instructions

    • 30 - 210 applications (Procedure dependent)

    • CPT codes and MSDS included

    • Shipping — No HAZMAT fees

    H-60 Convenience Kit Large

    H-60 Convenience Kit Large

    • Ideal for every exam room and practices treating a variety   of different lesion

    • Lower cost per treatment – No Freeze-Thaw-Freeze   Procedure

    • 170mL cryogen canister with 30 (2mm) and 30 (5mm)   applicators, detailed instructions

    • 60 - 420 applications (Procedure dependent)

    • CPT codes and MSDS included

    H-505 5mm Specialty Kit

    H-505 5mm Specialty Kit

    • Designed to treat larger lesions or Plantar Warts

    • Lower cost per treatment – No Freeze-Thaw-Freeze   Procedure

    • 170mL cryogen canister with 50 (5mm) applicators, detailed   instructions

    • 50 - 400 applications (Procedure dependent)

    • CPT codes and MSDS included

    H-602 2mm Specialty Kit

    H-602 2mm Specialty Kit

    • Ideal for OB/GYN and Pediatric practices for treatment of   Condyloma, Molluscum, skin tags and small warts and benign   lesions

    • Lower cost per treatment – No Freeze-Thaw-Freeze   Procedure

    • 170mL cryogen canister with 60 (2mm) applicators, detailed   instructions

    • 60 - 360 applications (Procedure dependent)

    • CPT codes and MSDS included

    Note: Please check with your supplier for more information about available products in your region.

    back to top
  8. How many treatments will it take to resolve a lesion?

    Lesions are resolved in one to four treatments with two-week intervals between treatments.

    back to top
  9. What is the shelf life of the product?

    Two years from the date of manufacture for H-30. Three years from the date of manufacture for H-60, H-505 and H-602 products.

    back to top
  10. Do I need to store the Histofreezer Portable Cryosurgical System kit in the freezer or refrigerator?

    Histofreezer does not require refrigeration. Do not store at temperatures above 50°C. See the Histofreezer Material Safety Data Sheet. (MSDS)

    back to top
  11. How effective is the Histofreezer Portable Cryosurgical System product?

    A study showed an average rate of 93.4% effectiveness for a variety of lesions.1

    back to top
  12. How many applications can you perform with one saturated Histofreezer applicator?

    After saturation of a 5mm Histofreezer applicator, you may perform a second application on the same patient after a 15-second pause between applications. The use time of a saturated 5mm Histofreezer applicator is 120 seconds.

    After saturation of a 2mm Histofreezer applicator, you may perform a second application on the same patient after a 15-second pause between applications. The use time of a saturated 2mm Histofreezer applicator is 90 seconds.

    Note: Refer to the Histofreezer Instructions for Use for the lesion-specific treatment times.

    back to top
  13. When using the Histofreezer Portable Cryosurgical System, do I need to perform a freeze-thaw-freeze procedure during a single patient visit?

    No. A freeze-thaw-freeze procedure is not required during a single patient visit when using the Histofreezer product.

    back to top


  14. What is the best technique to ensure the applicator bud reaches the right temperature?

    Hold the canister in the upright position. Charge the bud until droplets form. Stop charging, invert the canister with the bud pointing to the floor and wait 15 seconds before treating the lesion.

    Histofreezer® Portable Cryosurgical System Demonstration Video Click Here to View Histofreezer Demonstration Video


    back to top
  15. How cold does the applicator get?

    The applicator temperature reaches -55°C, which minimizes risk of scarring or blistering of the treatment site.

    back to top
  16. Can I re-use the applicator buds?

    Do not use a used applicator for another patient due to risk of cross-contamination. A sufficient supply of applicators is included with each kit.

    back to top
  17. Can Histofreezer treat vaginal or cervical condyloma?

    No. Histofreezer has been approved for external condyloma lesions only. This would include any condyloma for anogenital, labial and penile lesions.

    back to top
  18. What happens if the cryogen gas drips onto the floor or clothing?

    The Dimethyl Ether, Propane, and Isobutane gas in the Histofreezer canister is a clear liquefied gas that is not harmful to clothing or furniture. Any drips that occur can be simply washed off with a mild soap and will not leave any stains.

    back to top

Page last updated: October 21, 2009


HISTOFREEZER — CLINICALLY PROVEN, SAFE AND EASY-TO-USE

Bookmark and Share Site developed by Expect Advertising, Inc. Find us on Facebook